Not known Factual Statements About phenobarbital sodium drug class
Not known Factual Statements About phenobarbital sodium drug class
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pentobarbital will reduce the extent or effect of amlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will lessen the extent or effect of alosetron by affecting hepatic enzyme CYP2C9/ten metabolism. Minor/Significance Unidentified.
pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with strong CYP3A4 inducers; these drugs cut down publicity to vandetanib by nearly forty%.
pentobarbital will lower the level or effect of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital improves toxicity of buprenorphine, extensive-performing injection by pharmacodynamic synergism. Modify Therapy/Keep track of Carefully. Coadministration of buprenorphine and benzodiazepines or other CNS depressants boosts danger of adverse reactions like overdose, respiratory depression, and Demise. Cessation of benzodiazepines or other CNS depressants is most well-liked generally.
pentobarbital will lessen the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. The efficacy of hormonal contraceptives can be decreased. Usage of a nonhormonal contraceptive is usually recommended.
Data with the affected individual: Practitioners should really give the following data and directions to people receiving barbiturates. The use of barbiturates carries with it an affiliated hazard of psychological and/or physical dependence. The individual really should be warned towards raising the dose in the drug without consulting a physician.
pentobarbital will lower the level or effect of nelfinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will decrease the level or effect more info of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will minimize the extent or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Inspection: Parenteral drug products needs to be inspected visually for particulate make any difference and discoloration before administration, When solution containers permit. Solutions for injection exhibiting evidence of precipitation really should not be used.
fentanyl transmucosal and pentobarbital both maximize sedation. Stay away from or Use Alternate Drug. Limit use to sufferers for whom alternative treatment method possibilities are insufficient
pentobarbital will minimize the level or effect of paclitaxel protein bound by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.
pentobarbital will decrease the extent or effect of cilostazol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.